About ALS Biopharma
3805 Old Easton Road
Doylestown, PA 18902
Location and Facilities
Our laboratories at the PBC include a complete array of chemistry and biochemistry tools and equipment such as a real time PCR, laminar flow hoods, table top centrifuges, Thermofinnagan LCQ and ABI Qtrap Mass Specs, Waters HPLC systems, a Biomek robot liquid handler, and other equipment that is routine for modern molecular biology, high throughput screening, and medicinal chemistry.
Cassel, J. A.; McDonnell, M. E.; Velvadapu, V.; Andrianov, V.; Reitz, A. B. The effects of small molecule inhibitors of nucleic acid binding to TDP-43 on TDP-43 metabolism and function. Biochimie, 2012, 94, 1974-1981.
Cassel, J. A.; McDonnell, M. E.; Velvadapu, V.; Andrianov, V.; Reitz, A. B. Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function. Biochemie, 2012, 94, 1974-1981.
Cassel, J. A.; Ilyin, S.; McDonnell, M. E.; Reitz, A. B. Novel Inhibitors of Heat Shock Protein Hsp70-Mediated Luciferase Refolding that Bind to DnaJ., Bioorg. Med. Chem. Lett. 2012, 20, 3609-3614.
Pawlyk, A. C.; Cassel, J. A.; Reitz, A. B. Current Nervous System Related Drug Targets for the Treatment of Amyotrophic Lateral Sclerosis. Curr. Pharm. Des. 2010, 16, 2053.
Cassel, J. A.; Blass, B. E.; Reitz, A. B.; Pawlyk, A. C. Development of a Nonradiometric Assay for Nucleic Acid Binding to TDP-43 Suitable for High-Throughput Screening Using AlphaScreen® Technology. J. Biomolecular Screening, 2010, 15, 1099-1106.